Panama City the City with the Canal.
I tell you why I think you can skip watching the Panama Canal.
incl. David (Chiriqui)
Boquete, the place in the mountains above David in the Chiriqui province has lots of Free Adventures.
Next to Panama City and Boquete are Santa Catalina, Coronado, San Blas and Bocas Del Torro.
Hurricanes almost never hit Panama so other than bigger storms, there is nothing to worry about during the Hurricane season from September to November.
Due to the pretty developed state of Panama there are not many Animals or aggressive Stray Dogs even in most of the country side. But in especially in the Chiriqui, there can be some venomous spiders and snakes in the jungle.
Panama is no third world country and should be not compared to another one. Be aware that Panama got independence from Colombia in 1903. So no inappropriate jokes about that.
1983-1989 the country fell in dark times with the regime of Manuel Noriega who acted like a maniac as the head of the country. With help from the USA, Noriega was convicted for drug trafficking and left a destroyed country behind.
So no jokes about dictatorship or related topics.
All of Panama is surprisingly safe.
Especially the area Chiriqui and all the countryside of Panama. Panama City can be considered like a big US city with good and bad parts. See my Map for more info about where not to go.
The city of Colon on the north side of the Panama Canal should be avoided. Not just because there is nothing to see, but because it's a poor and dangerous town.
This part of Panama should not be visited without a guide because there are still drug trafficking gangs in the national forest and some parts are controlled by para military movements (Guerilla) in that part of the country. My advice, is not to go further east than the Tocumen airport, unless you know what you are doing.
These are the colorful buses driving around Panama City.
Those are used by the poorer people of Panama on a daily bases and are no tourist attraction.
Driving with them should be avoided.